THE PROTECTIVE EFFICACY OF RECOMBINANT HEPATITIS-B VACCINE IN NEWBORN-INFANTS OF HEPATITIS-B E ANTIGEN-POSITIVE-HEPATITIS-B SURFACE-ANTIGEN CARRIER MOTHERS

被引:56
作者
LEE, CY
HUANG, LM
CHANG, MH
HSU, CY
WU, SJ
SUNG, JL
SAFARY, A
机构
[1] TAIPEI MUNICIPAL WOMENS & CHILDRENS HOSP,DEPT PEDIAT,TAIPEI,TAIWAN
[2] SMITH KLINE BIOL,RIXENSART,BELGIUM
[3] TAIPEI MUNICIPAL WOMENS & CHILDRENS HOSP,DEPT OBSTET,TAIPEI,TAIWAN
[4] NATL TAIWAN UNIV,MED CTR,DEPT PEDIAT,TAIPEI,TAIWAN
[5] NATL TAIWAN UNIV,MED CTR,DEPT INTERNAL MED,TAIPEI,TAIWAN
关键词
D O I
10.1097/00006454-199104000-00007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recombinant hepatitis B vaccine has been shown to be as safe and effective as plasma-derived vaccines. However, its efficacy in the prevention of perinatal infection has not been fully evaluated in an endemic area. We recruited 110 high risk infants born to hepatitis B e antigen-positive-hepatitis B surface antigen (HBsAg) carrier mothers in a study of recombinant vaccine efficacy. They were randomized into 2 groups, A (54 infants) and B (56 infants), to receive 4 doses of vaccine, containing 20 or 10-mu-g of surface antigen, respectively, at 0, 1, 2 and 12 months of age. An additional 60 high risk infants were recruited later (Group C) and received three 20-mu-g doses of vaccine at 0, 1 and 6 months of age. All infants also received a dose (145 IU) of hepatitis B immunoglobulin soon after birth. Sera were collected at 0, 1, 2, 3, 6, 12 and 14 months of age to assay HBsAg and anti-HBs. At 12 months of age the HBsAg carrier rates were 7.4 and 1.8%, in Groups A and B, respectively. In Group C the HBsAg-positive rate was 3.3%. HBsAg was invariably first observed between 0 and 2 months of age. Virtually all noncarrier infants developed substantial titers of anti-HBs at 12 months of age. No serious adverse effect was observed after vaccination.
引用
收藏
页码:299 / 303
页数:5
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