DIASTEREOSELECTIVE ALKYLATION OF TRICARBONYL(METHYL 3,5-HEXADIENOATE)IRON

被引：11

作者：

DONALDSON, WA ^{[1
]}

CRAIG, R ^{[1
]}

SPANTON, S ^{[1
]}

机构：

[1] ABBOTT LABS,DIV PHARMACEUT DISCOVERY,ABBOTT PK,IL 60064

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 28期

关键词：

D O I：

10.1016/0040-4039(92)88074-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylation of the anion of the title compound with iodomethane, benzylbromide, or allyl bromide proceeds in a highly diastereoselective fashion to afford tricarbonyl(2S*,3R* methyl 2-substituted-3,5-hexadienoate)iron complexes. The relative stereochemistry of the methylation product 2a was determined by single X-ray crystallographic analysis of the corresponding diastereomeric carboxylic acid 4b.

引用

页码：3967 / 3968

页数：2

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