INCREASED EXPRESSION OF CYTOKERATIN-8, CYTOKERATIN-18 AND VIMENTIN IN THE INVASION FRONT OF MUCOSAL SQUAMOUS-CELL CARCINOMA

被引:87
作者
SCHAAFSMA, HE
VANDERVELDEN, LA
MANNI, JJ
PETERS, H
LINK, M
RUITER, DJ
RAMAEKERS, FCS
机构
[1] CANISIUS WILHELMINA HOSP,DEPT PATHOL,NIJMEGEN,NETHERLANDS
[2] UNIV HOSP NIJMEGEN,DEPT OTORHINOLARYNGOL,NIJMEGEN,NETHERLANDS
[3] UNIV LIMBURG,DEPT MOLEC CELL BIOL & GENET,6200 MD MAASTRICHT,NETHERLANDS
关键词
CYTOKERATIN; VIMENTIN; SQUAMOUS CELL CARCINOMA; INVASION;
D O I
10.1002/path.1711700113
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The immunohistochemical expression patterns of cytokeratins 8 and 18 and vimentin were examined in frozen sections of 120 human mucosal squamous cell carcinomas with special emphasis on the topological distribution in the tumour. This was done in order to evaluate in squamous cell carcinoma a particular expression pattern observed recently by us in transitional cell carcinoma of the urinary tract and designated as an 'interface phenomenon'. This phenomenon implying maximum expression of cytokeratins 8 and 18 at the tumour front, and to a lesser extent also in areas of intratumorous stroma contact, was also found in about 50 per cent of the squamous cell carcinomas examined. It was even found for vimentin, which contrasted with transitional cell carcinoma. The percentages of occurrence of the phenomenon varied for the different sites of origin of the tumour. Tumour grade did not influence the results. These findings further support the idea that invasive carcinoma cells interacting with the stromal micro-environment display a characteristic intermediate filament phenotype that deviates from the pattern expected on the basis of their direction of differentiation. These changes might reflect phenotype involved in invasive, migrating, and proliferating activities.
引用
收藏
页码:77 / 86
页数:10
相关论文
共 30 条
[1]   EXPRESSION OF SIMPLE EPITHELIAL TYPE CYTOKERATINS IN STRATIFIED EPITHELIA AS DETECTED BY IMMUNOLOCALIZATION AND HYBRIDIZATION INSITU [J].
BOSCH, FX ;
LEUBE, RE ;
ACHTSTATTER, T ;
MOLL, R ;
FRANKE, WW .
JOURNAL OF CELL BIOLOGY, 1988, 106 (05) :1635-1648
[2]  
BROERS JLV, 1988, CANCER RES, V48, P3221
[3]  
DOMAGALA W, 1990, AM J PATHOL, V137, P1299
[4]   PROGNOSTIC-SIGNIFICANCE OF VIMENTIN POSITIVITY IN FORMALIN-FIXED RENAL-CELL CARCINOMAS [J].
DONHUIJSEN, K ;
SCHULZ, S .
PATHOLOGY RESEARCH AND PRACTICE, 1989, 184 (03) :287-291
[5]  
FISCHER HP, 1989, LAB INVEST, V61, P433
[6]  
FUCHS E, 1981, CELL, V25, P617, DOI 10.1016/0092-8674(81)90169-0
[7]   THE EXPRESSION OF INTERMEDIATE FILAMENTS AND MAM-6 ANTIGEN IN RELATION TO THE DEGREE OF MORPHOLOGIC DIFFERENTIATION OF CARCINOMA OF THE HEAD AND NECK - DIAGNOSTIC IMPLICATIONS [J].
HENZENLOGMANS, SC ;
BALM, AJM ;
VANDERWAAL, I ;
MULLINK, H ;
SNOW, GB ;
MEYER, CJLM .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1988, 99 (06) :539-547
[8]   NEW MONOCLONAL-ANTIBODIES RECOGNIZING EPIDERMAL DIFFERENTIATION-ASSOCIATED KERATINS IN FORMALIN-FIXED, PARAFFIN-EMBEDDED TISSUE - KERATIN-10 EXPRESSION IN CARCINOMA OF THE VULVA [J].
IVANYI, D ;
ANSINK, A ;
GROENEVELD, E ;
HAGEMAN, PC ;
MOOI, WJ ;
HEINTZ, APM .
JOURNAL OF PATHOLOGY, 1989, 159 (01) :7-12
[9]   BASEMENT-MEMBRANE HETEROGENEITY AND VARIATION IN CORNEAL EPITHELIAL DIFFERENTIATION [J].
KOLEGA, J ;
MANABE, M ;
SUN, TT .
DIFFERENTIATION, 1989, 42 (01) :54-63
[10]  
Lane E B, 1990, Semin Cancer Biol, V1, P165