PHARMACOKINETICS OF DICLOFENAC AND 5 METABOLITES AFTER SINGLE DOSES IN HEALTHY-VOLUNTEERS AND AFTER REPEATED DOSES IN PATIENTS

被引：31

作者：

DEGEN, PH

DIETERLE, W

SCHNEIDER, W

THEOBALD, W

SINTERHAUF, U

机构：

[1] CIBA GEIGY AG,DIV PHARMACEUT,DEPT MED,CH-4002 BASEL,SWITZERLAND

[2] CIBA GEIGY GMBH,CLIN RES,FRANKFURT,FED REP GER

来源：

XENOBIOTICA | 1988年 / 18卷 / 12期

关键词：

D O I：

10.3109/00498258809042267

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：1449 / 1455

页数：7

共 12 条

[1]

FAIGLE JW, 1988, XENOBIOTICA, V18, P1195

[2] PLASMA AND SYNOVIAL-FLUID CONCENTRATIONS OF DICLOFENAC SODIUM AND ITS HYDROXYLATED METABOLITES DURING ONCE-DAILY ADMINISTRATION OF A 100 MG SLOW-RELEASE FORMULATION [J].

FOWLER, PD ;

DAWES, PT ;

JOHN, VA ;

SHOTTON, PA .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 31 (04) :469-472

[3]

KHANNA S, 1985, Patent No. 4510128

[4]

KHANNA S, 1986, Patent No. 2134529

[5]

RIESS W, 1978, SCAND J RHEUMATOL, P17

[6]

RIESS W, 1976, THERAPIEWOCHA, V26, P18

[7] SIMULTANEOUS DETERMINATION OF DICLOFENAC SODIUM AND ITS HYDROXY METABOLITES BY CAPILLARY COLUMN GAS-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION [J].

SCHNEIDER, W ;

DEGEN, PH .

JOURNAL OF CHROMATOGRAPHY, 1981, 217 (NOV) :263-271

[8] SIMULTANEOUS DETERMINATION OF DICLOFENAC SODIUM AND ITS METABOLITES IN PLASMA BY CAPILLARY COLUMN GAS-CHROMATOGRAPHY WITH ELECTRON-CAPTURE DETECTION [J].

SCHNEIDER, W ;

DEGEN, PH .

JOURNAL OF CHROMATOGRAPHY, 1986, 383 (02) :412-418

[9] BIOTRANSFORMATION OF DICLOFENAC SODIUM (VOLTAREN) IN ANIMALS AND IN MAN .1. ISOLATION AND IDENTIFICATION OF PRINCIPAL METABOLITES [J].

STIERLIN, H ;

FAIGLE, JW ;

SALLMANN, A ;

KUNG, W ;

RICHTER, WJ ;

KRIEMLER, HP ;

ALT, KO ;

WINKLER, T .

XENOBIOTICA, 1979, 9 (10) :601-610

[10] BIOTRANSFORMATION OF DICLOFENAC SODIUM (VOLTAREN) IN ANIMALS AND IN MAN .2. QUANTITATIVE-DETERMINATION OF THE UNCHANGED DRUG AND PRINCIPAL PHENOLIC METABOLITES, IN URINE AND BILE [J].

STIERLIN, H ;

FAIGLE, JW .

XENOBIOTICA, 1979, 9 (10) :611-621

← 1 2 →