DNA PLOIDY IN PRIMARY TESTICULAR CANCER

被引:25
作者
FOSSA, SD
NESLAND, JM
PETTERSEN, EO
AMELLEM, O
WAEHRE, H
HEIMDAL, K
机构
[1] NORWEGIAN RADIUM HOSP,DEPT SURG ONCOL,N-0310 OSLO 3,NORWAY
[2] NORWEGIAN RADIUM HOSP,DEPT PATHOL,N-0310 OSLO 3,NORWAY
[3] NORWEGIAN RADIUM HOSP,DEPT TISSUE CULTURE,N-0310 OSLO 3,NORWAY
关键词
D O I
10.1038/bjc.1991.432
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The DNA stemline ploidy was measured by flow cytometry (FCM) in 129 samples from paraffin-embedded primary testicular tumours (61 seminomas, 68 non-seminomas). Only one DNA stemline was found in 38 seminomas and 44 non-seminomas. Two seminomas and one non-seminoma were DNA diploid, the other tumours being non-diploid. Twenty-three seminomas and 24 non-seminomas displayed two or three DNA stemlines. The median minimal DNA index (DI) of all seminomas was significantly higher than that of all non-seminomas (1.58 vs 1.43; P: 0.008). Three seminomas removed from two monozygotic twins within 1 week had DIs of 1.66, 1.56 and 1.59. In this limited series there was no association between DNA ploidy of the primary tumour and the metastatic status for either seminomas or non-seminomas. The results support the pathogenetic model stating that at least some (if not all) non-seminomas develop from a seminoma by additional chromosomal aberration. The clinical relevance of DNA stemline ploidy has to be further evaluated in larger series.
引用
收藏
页码:948 / 952
页数:5
相关论文
共 26 条
[1]   HIGH CHROMOSOME-NUMBERS OF SEMINOMATA AND MALIGNANT TERATOMATA OF TESTIS - REVIEW OF DATA ON 103 TUMORS [J].
ATKIN, NB .
BRITISH JOURNAL OF CANCER, 1973, 28 (03) :275-279
[2]  
BOSL GJ, 1989, J NATL CANCER I, V81, P1874
[3]   DNA FLOW-CYTOMETRY OF CELLS OBTAINED FROM OLD PARAFFIN-EMBEDDED SPECIMENS - A COMPARISON WITH RESULTS OF SCANNING ABSORPTION CYTOMETRY (A METHODOLOGICAL STUDY) [J].
FOSSA, SD ;
THORUD, E ;
SHOAIB, MC ;
PETTERSEN, EO .
PATHOLOGY RESEARCH AND PRACTICE, 1986, 181 (02) :200-205
[4]   TESTICULAR CANCER IN YOUNG NORWEGIANS [J].
FOSSA, SD ;
AASS, N ;
KAALHUS, O .
JOURNAL OF SURGICAL ONCOLOGY, 1988, 39 (01) :43-63
[5]  
FOSSA SD, 1991, IN PRESS CANCER
[6]  
FRIEDMAN NB, 1951, CANCER, V4, P265, DOI 10.1002/1097-0142(195103)4:2<265::AID-CNCR2820040211>3.0.CO
[7]  
2-X
[8]  
GUSTAFSON H, 1982, UROL RES, V10, P13
[9]   METHOD FOR ANALYSIS OF CELLULAR DNA CONTENT OF PARAFFIN-EMBEDDED PATHOLOGICAL MATERIAL USING FLOW-CYTOMETRY [J].
HEDLEY, DW ;
FRIEDLANDER, ML ;
TAYLOR, IW ;
RUGG, CA ;
MUSGROVE, EA .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1983, 31 (11) :1333-1335
[10]   CONVENTION ON NOMENCLATURE FOR DNA CYTOMETRY [J].
HIDDEMANN, W ;
SCHUMANN, J ;
ANDREEF, M ;
BARLOGIE, B ;
HERMAN, CJ ;
LEIF, RC ;
MAYALL, BH ;
MURPHY, RF ;
SANDBERG, AA .
CANCER GENETICS AND CYTOGENETICS, 1984, 13 (02) :181-183