CHARACTERIZATION OF 2 NOVEL SUBUNITS OF THE ALPHA-CLASS GLUTATHIONE S-TRANSFERASES OF HUMAN LIVER

被引：13

作者：

AHMAD, H ^{[1
]}

SINGHAL, SS ^{[1
]}

SAXENA, M ^{[1
]}

AWASTHI, YC ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT HUMAN BIOL CHEM & GENET,2138 MED RES BLDG,J-67,GALVESTON,TX 77555

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1161卷 / 2-3期

关键词：

GLUTATHIONE S-TRANSFERASE; SUBUNIT; AMINO ACID SEQUENCE; (HUMAN);

D O I：

10.1016/0167-4838(93)90234-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

More than 85% of the complete amino-acid sequence of the alpha-class glutathione S-transferase omega (GST omega) of human liver, described for the first time in this communication, show that GST omega is a heterodimer of two closely related novel alpha-class GST subunits. The sequences of these subunits, omega1 and omega2, have over 97% homology between them and are also highly homologous to the two alpha-class subunits characterized previously. Characterization of these two novel alpha-class subunits described in this report would explain the molecular basis for high degree of heterogeneity observed among the alpha-class human GSTs.

引用

页码：333 / 336

页数：4

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