ISOLATION, CHARACTERIZATION AND STRUCTURE OF A NEW ALLENIC POLYINE ANTIBIOTIC PRODUCED BY FUNGUS LL-07F275

被引：14

作者：

SCHLINGMANN, G

MILNE, L

PEARCE, CJ

BORDERS, DB

GREENSTEIN, M

MAIESE, WM

CARTER, GT

机构：

[1] American Cyanamid Company, Medical Research Division, Natural Products Research Section, Lederle Laboratories, Pearl River

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 05期

关键词：

D O I：

10.7164/antibiotics.48.375

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antibiotic 07F275 (1), produced by submerged fermentations of fungal culture LL-07F275, was isolated and characterized despite its inherent instability. Its UV spectrum was identical with that of nemotin, a member of the allenic polyacetylene family, but a molecular weight of 218 daltons indicated a new compound. Structure 1 was determined on the basis of spectroscopic evidence, particularly NMR. Since 1 is a thirteen carbon-containing allenic diyne, it is closely related to mycomycin.

引用

页码：375 / 379

页数：5

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