FLUOXETINE EFFECTS ON CEREBRAL GLUCOSE-METABOLISM

被引:25
作者
COOK, EH
METZ, J
LEVENTHAL, BL
LEBOVITZ, M
NATHAN, M
SEMERDJIAN, SA
BROWN, T
COOPER, MD
机构
[1] UNIV CHICAGO,FRANKLIN MCLEAN MEM RES INST,PET CTR,CHICAGO,IL 60637
[2] ILLINOIS STATE PSYCHIAT INST,CHICAGO,IL 60612
关键词
PET; FLUOXETINE; SEROTONIN; CEREBRAL METABOLISM; IMAGE ANALYSIS; LIMBIC SYSTEM; HIPPOCAMPUS; AMYGDALA;
D O I
10.1097/00001756-199409080-00014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
IN a counterbalanced, double-blind, placebo-controlled trial, 40 mg of fluoxetine was administered to four healthy adult volunteers (three men, one woman; age range 20-39 years), 90 min before injection of 6-7.5 mCi of [F-18]-2-deoxyglucose to measure cerebral metabolic rate of glucose (CMRglu). Subjects were engaged in a visual monitoring task shortly before and during scanning with a PETT-VI tomograph. Global CMRglu did not differ when placebo (8.93 +/- 0.96 mg 100 g(-1) min(-1)) was compared to fluoxetine (8.22 +/- 0.86 mg 100 g(-1) min(-1); paired t-test = 0.82, df = 3, p < 0.48). However, statistical parametric mapping of differences in CMRglu between placebo and fluoxetine conditions revealed regional effects of fluoxetine shown by decreased metabolism in the amygdaloid complex, hippocampal formation and ventral striatum, and by increased metabolism centered in the right superior parietal lobe (Brodmann area 7). Parametric mapping for use in PET studies of glucose metabolism represents a significant new tool for studying drug effects in humans.
引用
收藏
页码:1745 / 1748
页数:4
相关论文
共 26 条
[1]  
BAXTER LR, 1992, ARCH GEN PSYCHIAT, V49, P681
[2]   FLUOXETINE - A REVIEW OF RECEPTOR AND FUNCTIONAL-EFFECTS AND THEIR CLINICAL IMPLICATIONS [J].
BEASLEY, CM ;
MASICA, DN ;
POTVIN, JH .
PSYCHOPHARMACOLOGY, 1992, 107 (01) :1-10
[3]   SPIPERONE DIFFERENTIATES MULTIPLE 5-HYDROXYTRYPTAMINE RESPONSES IN RAT HIPPOCAMPAL SLICES INVITRO [J].
BECK, SG ;
CLARKE, WP ;
GOLDFARB, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 116 (1-2) :195-197
[4]  
BENKELFAT C, 1990, ARCH GEN PSYCHIAT, V47, P840
[5]  
BLIER P, 1993, J PHARMACOL EXP THER, V265, P7
[6]   QUANTITATIVE AUTORADIOGRAPHY OF H-3 PAROXETINE BINDING-SITES IN RAT-BRAIN [J].
CHEN, HT ;
CLARK, M ;
GOLDMAN, D .
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 1992, 27 (04) :209-216
[7]   FENFLURAMINE AND CEREBRAL GLUCOSE [J].
COOK, EH ;
METZ, J ;
COOPER, MD ;
CHOU, JS ;
LEVENTHAL, BL .
BIOLOGICAL PSYCHIATRY, 1992, 31 (11) :1173-1174
[8]   FLUOXETINE TREATMENT OF CHILDREN AND ADULTS WITH AUTISTIC DISORDER AND MENTAL-RETARDATION [J].
COOK, EH ;
ROWLETT, R ;
JASELSKIS, C ;
LEVENTHAL, BL .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1992, 31 (04) :739-745
[9]   PARIETAL LOBE ABNORMALITIES DETECTED WITH MR IN PATIENTS WITH INFANTILE-AUTISM [J].
COURCHESNE, E ;
PRESS, GA ;
YEUNGCOURCHESNE, R .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1993, 160 (02) :387-393
[10]   MAPPING HUMAN VISUAL-CORTEX WITH POSITRON EMISSION TOMOGRAPHY [J].
FOX, PT ;
MINTUN, MA ;
RAICHLE, ME ;
MIEZIN, FM ;
ALLMAN, JM ;
VANESSEN, DC .
NATURE, 1986, 323 (6091) :806-809