INHIBITION OF THE 5-HT3 RECEPTOR-MEDIATED CURRENT BY THE PROTEIN-KINASE INHIBITOR, H-7

被引：5

作者：

FAN, P

机构：

[1] Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852

来源：

BRAIN RESEARCH | 1994年 / 649卷 / 1-2期

关键词：

NODOSE GANGLION; 5-HT3; RECEPTOR; PATCH CLAMP; H-7; H-8; PROTEIN KINASE;

D O I：

10.1016/0006-8993(94)91078-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the protein kinase inhibitor, H-7, on the inward current mediated by 5-HT3 receptors was investigated with the whole-cell patch-clamp technique. H-7 inhibited the peak 5-HT current with an IC50 of 1.79 mu M. The inhibition was quick, reversible and not blocked by the presence of 50 mu M intracellular H-7. It is concluded that the effect of H-7 was independent of protein kinase activity.

引用

页码：310 / 312

页数：3

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