OP-1 CDNA ENCODES AN OSTEOGENIC PROTEIN IN THE TGF-BETA FAMILY

被引:511
作者
OZKAYNAK, E
RUEGER, DC
DRIER, EA
CORBETT, C
RIDGE, RJ
SAMPATH, TK
OPPERMANN, H
机构
关键词
bone morphogenesis; consensus gene; differentiation; growth factor; supergene family;
D O I
10.1002/j.1460-2075.1990.tb07376.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Amino acid sequences of two tryptic peptides derived from enriched bovine osteogenic protein preparations revealed considerable homology to two members of the TGF-β (transforming growth factor β) supergene family, DPP (decapentaplegic protein) of Drosophila and Vg-1 (vegetal protein) of Xenopus. Building upon this information we constructed a synthetic consensus gene to use as a probe to screen human genomic libraries. This resulted in the isolation of three interrelated genes. Among these were BMP-2b and BMP-3 which have recently been described by others. The third gene, termed OP-1 (osteogenic protein one), is new and was subsequently shown to encode the human homolog of a major component of bovine osteogenic protein. The genomic clones were used to isolate the corresponding complementary DNA (cDNA) clones. Sequence analysis indicates that OP-1 is a relative of the murine Vgr-1 (Vg-1 related gene). This report describes the cDNA structure and putative amino acid sequence of OP-1.
引用
收藏
页码:2085 / 2093
页数:9
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