A DOUBLE-BLIND, CONTROLLED TRIAL OF BIOFLORIN (STREPTOCOCCUS-FAECIUM SF68) IN ADULTS WITH ACUTE DIARRHEA DUE TO VIBRIO-CHOLERAE AND ENTEROTOXIGENIC ESCHERICHIA-COLI

被引：61

作者：

MITRA, AK

RABBANI, GH

机构：

[1] International Centre for Diarrheal Disease Research, Dhaka

来源：

GASTROENTEROLOGY | 1990年 / 99卷 / 04期

关键词：

D O I：

10.1016/0016-5085(90)90638-H

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The therapeutic efficacy of Bioflorin (Streptococcus faecium SF68; Gipharmex, Milan, Italy) in acute watery diarrhea was evaluated in 183 Bangladeshi adults. Vibrio cholerae organisms were isolated from stool cultures in 114 patients, and enterotoxigenic Escherichia coli organisms were isolated in 41. In addition to IV rehydration, patients were randomly assigned to receive either capsules of Bioflorin containing 1 × 109 of live SF68 or capsules of placebo containing killed SF68 once every 8 hours for 3 days. No other drugs were allowed during this period. Bioflorin was well tolerated. It is concluded that Bioflorin has no demonstrable antidiarrheal property in adults with acute diarrhea due to V. cholerae or enterotoxigenic E. coli infection. © 1990.

引用

页码：1149 / 1152

页数：4

共 13 条

[1]

BELLOMO G, 1980, CURR THER RES CLIN E, V28, P927

[2]

BENENSON A. S., 1964, BULL WORLD HEALTH ORGAN, V30, P827

[3]

BORGIA M, 1983, CURR THER RES CLIN E, V33, P214

[4]

BORGIA M, 1982, CURR THER RES CLIN E, V31, P265