OKADAIC ACID STIMULATES THE ATP-DEPENDENT INTERACTION BETWEEN ACTIN AND MYOSIN OF SMOOTH-MUSCLE VIA A DIRECT EFFECT ON MYOSIN

被引：20

作者：

HAYAKAWA, K

OKAGAKI, T

DOBASHI, T

SAKANISHI, A

KANEKO, K

KOHAMA, K

机构：

[1] GUNMA UNIV,SCH MED,DEPT PHARMACOL,MAEBASHI,GUNMA 371,JAPAN

[2] GUNMA UNIV,FAC ENGN,DEPT BIOL & CHEM ENGN,KIRYU,GUNMA 376,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 177卷 / 03期

关键词：

D O I：

10.1016/0006-291X(91)90660-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The direct effect of okadaic acid (OA) on the ATP-dependent interaction between actin and myosin of smooth muscle was examined not only by the conventional measurement of ATPase activity but also by application of in vitro motility assay developed recently. The motility was effectively enhanced by μM levels of OA. Measurements of the activities of myosin confirmed that the myosin mediated this effect. The result of this study, which was carried out in the absence of protein phosphatase, are not compatible with the recent reports that the stimulatory effect of OA on smooth muscle contraction is attributable to its inhibitory effect on the activity of the protein phosphatase. © 1991.

引用

页码：1155 / 1160

页数：6

共 23 条

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