ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM IN HYPERTROPHIC CARDIOMYOPATHY AND SUDDEN CARDIAC DEATH

被引：347

作者：

MARIAN, AJ ^{[1
]}

YU, QT ^{[1
]}

WORKMAN, R ^{[1
]}

GREVE, G ^{[1
]}

ROBERTS, R ^{[1
]}

机构：

[1] BAYLOR COLL MED,6535 FANNIN,MS F905,HOUSTON,TX 77030

来源：

LANCET | 1993年 / 342卷 / 8879期

关键词：

D O I：

10.1016/0140-6736(93)92064-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We determined the distribution frequency of angiotensin converting enzyme (ACE) polymorphism in 100 patients with hypertrophic cardiomyopathy and 106 of their unaffected siblings and offspring. The distribution of ACE genotypes was different in the two groups: allele D frequency of 0.69 in patients and 0 57 in relatives (p = 0.021). The frequency of allele D was also higher in hypertrophic cardiomyopathy families with a high incidence of sudden cardiac death than those with a low incidence (0.74 vs 0.55, p = 0.011). In 25 hypertrophic cardiomyopathy patients with a strong family history of sudden cardiac death the frequency of allele D was 0.82 (p = 0.001 vs normals).

引用

页码：1085 / 1086

页数：2

共 9 条

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