URETERAL OBSTRUCTION IN THE NEONATAL GUINEA-PIG - INTERACTION OF SYMPATHETIC-NERVES AND ANGIOTENSIN

被引：7

作者：

CHEVALIER, RL

THORNHILL, BA

机构：

[1] Department of Pediatrics, University of Virginia, School of Medicine, Charlottesville, 22908, VA

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 04期

关键词：

URETERAL OBSTRUCTION; NEONATE; RENINANGIOTENSIN SYSTEM; RENAL NERVES; SYMPATHETIC NERVOUS SYSTEM; GUINEA PIG;

D O I：

10.1007/BF00866723

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The contribution of sympathetic nerves to the hemodynamic effects of unilateral ureteral obstruction (UUO) was investigated in the neonatal guinea pig. The left ureter was partially constricted (or sham-operated) at birth, and sympathetic innervation was inhibited by guanethidine and compared with saline vehicle-treated animals. At 15-20 days of age, blood pressure, cardiac output, total vascular resistance (TVR), renal blood flow, and renal vascular resistance (RVR) were determined before and after infusion of enalapril. UUO reduced cardiac output, increased TVR, and increased RVR of the ipsilateral kidney, whereas guanethidine treatment had no additional effects. Enalapril decreased RVR only in obstructed kidneys and not in intact opposite kidneys of animals with UUO. This was not affected by guanethidine administration. In contrast, enalapril decreased RVR only in guanethidine-treated (but not saline-treated) sham-operated guinea pigs. Therefore, UUO increases angiotensin-dependent vascular tone of the ipsilateral kidney independent of renal innervation. However, UUO decreases angiotensin-mediated vascular tone of the contralateral kidney, an effect unmasked by sympathectomy.

引用

页码：441 / 446

页数：6

共 23 条

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