DNA MELTING ON YEAST RNA POLYMERASE-II PROMOTERS

被引：130

作者：

GIARDINA, C ^{[1
]}

LIS, JT ^{[1
]}

机构：

[1] CORNELL UNIV,DEPT BIOCHEM MOLEC & CELL BIOL,ITHACA,NY 14853

来源：

SCIENCE | 1993年 / 261卷 / 5122期

关键词：

D O I：

10.1126/science.8342041

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transcription-dependent DNA melting on the yeast GAL1 and GAL10 promoters was found to be more closely correlated with the TATA box than the transcription start site. On both these genes, melting begins about 20 base pairs downstream of the TATA box. Physical and genetic analyses suggest that RNA polymerase II associates with this region. Thus, the distance between promoter melting and the TATA box in yeast may be similar to that in higher eukaryotes, even though transcription initiates in a region about 10 to 90 base pairs farther downstream in yeast.

引用

页码：759 / 762

页数：4

共 24 条

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