EFFECTS OF NEOGLYCOPROTEINS ON PENETRATION OF PLASMODIUM-FALCIPARUM MEROZOITES INTO ERYTHROCYTES INVITRO

被引：26

作者：

SCHULMAN, S

LEE, YC

VANDERBERG, JP

机构：

[1] JOHNS HOPKINS UNIV, DEPT BIOL, BALTIMORE, MD 21218 USA

[2] JOHNS HOPKINS UNIV, MCCOLLUM PRATT INST, BALTIMORE, MD 21218 USA

来源：

JOURNAL OF PARASITOLOGY | 1984年 / 70卷 / 02期

关键词：

D O I：

10.2307/3281864

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Sugars conjugated to bovine serum albumin (neoglycoproteins) were tested for their ability to inhibit P. falciparum merozoite invasion of [human] red blood cells in an in vitro inhibition assay. The inhibitory effects of the neoglycoproteins on merozoite invasion of erythrocytes were determined by assessing 3H-hypoxanthine incorporation into the cultures. The only neoglycoprotein that caused significant inhibition was N-acetyl-glucosamine-bovine serum albumin. A comparison of the inhibitory effects of N-acetyl-glucosamine and N-acetyl-glucosamine-bovine serum albumin showed that N-acetyl-glucosamine-bovine serum albumin was 84-fold more effective than the free sugar in causing 50% inhibition of 3H-hypoxanthine incorporation.

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页码：213 / 216

页数：4

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