SECONDARY ALDOSTERONISM DOCUMENTED BY PLASMA-RENIN AND ALDOSTERONE CIRCADIAN-RHYTHM IN SUBJECTS WITH KIDNEY OR HEART-TRANSPLANTATION

被引：8

作者：

CUGINI, P

BATTISTI, P

DIPALMA, L

CAVALLINI, M

POZZILLI, P

SCIBILIA, G

LETIZIA, C

CASSISI, A

CIOLI, AR

MARINO, B

STIPA, V

SCAVO, D

机构：

[1] Institute of Clinica Medica II, Chirurgia del Cuore e dei Grossi Vasi University of Rome, Rome

[2] Institute of Clinica Chururgica I, Chirurgia del Cuore e dei Grossi Vasi University of Rome, 00161, Rome, La Sapienza

来源：

RENAL FAILURE | 1992年 / 14卷 / 01期

关键词：

ALDOSTERONE; ANGIOTENSIN; CORTISOL; CYCLOSPORINE; HEART TRANSPLANTATION; KIDNEY TRANSPLANTATION; RENIN; TRANSPLANTATION;

D O I：

10.3109/08860229209039119

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The circadian rhythm (CR) of plasma renin activity (PRA), plasma aldosterone (PA), and plasma cortisol (PC) was investigated in 8 patients with kidney transplantation, and in 10 patients with heart transplantation. Ten clinically healthy subjects were studied as controls. The transplanted patients were all under cyclosporine treatment associated with prednisone (PDN). Time-qualified levels of PRA and PA were seen to be higher than normal in both groups of transplanted patients. The analysis of PRA and PA circadian rhythm provided evidence for a systematically higher level of within-day concentrations. The higher level of oscillation suggests the occurrence of a condition of hyperreninemic hyperaldosteronism. The higher levels of PRA and PA 24-h values show no periodicity. The finding suggests the abrogation of the rhythmic function for renin-aldosterone system. The disappearance of PRA-PA circadian rhythm seems to be attributable to a side effect of immunosuppressive therapy.

引用

页码：69 / 76

页数：8

共 28 条

[1]

Armbruster H., Vetter H., Beckerhoff R., Nussberger J., Siegenthaler W., Diurnal variations of plasma aldosterone in supine man: Relationship to plasma renin activity and plasma Cortisol, Acta Endocrinol (Kbh), 80, pp. 95-103, (1975)

[2]

Bantle J.P., Nath K.A., Sutherland D.E.R., Najarian J.S., Ferris T.F., Effects of cyclosporine on the renin-angiotensin-aldosterone system and potassium excretion in renal transplant recipients, Arch Intern Med., 145, pp. 505-508, (1985)

[3]

Best J.B., Bett J.H.N., Coghlan J.P., Cran E.J., Scoggins B.A., Circulating angiotensin II and aldosterone levels during sodium restriction, Lancet, II, pp. 1253-1256, (1972)

[4]

Ceresa F., Chronobiological attempt to avoid the inhibitory corticoid effect during long term treatment, Chronobiologia, 1, pp. 271-279, (1974)

[5]

Cohen E.L., Conn J.W., Rovner D.R., Postural augmentation of plasma renin activity and aldosterone excretion in normal people, J Clin Invest., 46, pp. 418-428, (1967)

[6]

Cugini P., Manconi R., Serdoz R., Mancini A., Meucci T., Kinetic postural variations of plasma renin, aldosterone and Cortisol in healthy subjecs on normal and restricted sodium diet, Boll Soc Ital Biol Sper, 51, pp. 781-786, (1977)

[7]

Cugini P., Manconi R., Serdoz R., Mancini A., Meucci T., Scavo D., Rhythm characteristics of plasma renin, aldosterone and Cortisol in five subtypes of mesor-hypertension, J Endocrinol Invest., 3, pp. 143-147, (1980)

[8]

Gordon E.D., Wolfe L.K., Island D.P., Liddle G.W., A diurnal rhythm in plasma renin activity in man, J Clin Invest., 45, pp. 1587-1592, (1965)

[9]

Haber E., Koemer T., Page L.B., Kliman B., Application of radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects, J Clin Endocrinol Metab., 29, pp. 1349-1355, (1969)

[10]

Doe R.P., Vennes J.A., Flink B.B., Diurnal variations of 17-hydroxy-corticosteroids, sodium, potassium and creatinine in normal subjects and in cases of treated adrenal insufficiency and Cushing's syndrome, J Clin Endocrinol Metab., 20, pp. 253-262, (1960)

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