ACTIVATION OF HUMAN EOSINOPHIL AND NEUTROPHIL FUNCTIONS BY HEMATOPOIETIC GROWTH-FACTORS - COMPARISONS OF IL-1, IL-3, IL-5 AND GM-CSF

被引:65
作者
FABIAN, I
KLETTER, Y
MOR, S
GELLERBERNSTEIN, C
BENYAAKOV, M
VOLOVITZ, B
GOLDE, DW
机构
[1] ZAMENHOF SICK FUND CLIN, DEPT ALLERGY, TEL AVIV, ISRAEL
[2] HASHARON HOSP, DEPT PEDIAT, PETAH TIQWA, ISRAEL
[3] UNIV CALIF LOS ANGELES, SCH MED, DEPT MED, DIV HEMATOL ONCOL, LOS ANGELES, CA 90024 USA
关键词
D O I
10.1111/j.1365-2141.1992.tb08890.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We compared the effect of haematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1, IL-3, and IL-5 on the functional activation of human eosinophils and neutrophils from the same donor. All four colony-stimulating factors (CSF) enhanced the phagocytosis of Candida albicans by eosinophils and increased staphylococcal, but not Candida, killing. GM-CSF and IL-5 had a profound stimulating effect on eosinophil staphylocidal activity. GM-CSF and IL-3 enhanced the generation of leukotriene C4 (LTC4) induced by calcium ionophore A23187 and the release of arylsulphatase and beta-glucuronidase from specific and small granules of eosinophils. In contrast, IL-1 and IL-5 had no effect on degranulation. GM-CSF and IL-1 enhanced phagocytosis of C. albicans by neutrophils, and GM-CSF stimulated degranulation and the release of the enzymes beta-glucuronidase and arylsulphatase from neutrophils while IL-1 stimulated the release of arylsulphatase only. This study indicates that the eosinophilactive colony-stimulating factors can markedly enhance the host defence function of the eosinophil and even make it the equal of the neutrophil in staphylocidal activity. The CSF-activated eosinophil, however, may cause inappropriate inflammation and normal tissue damage.
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页码:137 / 143
页数:7
相关论文
共 35 条
  • [1] ANWAR ARE, 1980, J IMMUNOL, V124, P1122
  • [2] ANWAR ARE, 1979, J IMMUNOL, V122, P628
  • [3] METABOLIC AND BACTERICIDAL ACTIVITIES OF HUMAN EOSINOPHILS
    BAEHNER, RL
    JOHNSTON, RB
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1971, 20 (03) : 277 - &
  • [4] EOSINOPHILS AS MEDIATORS OF ANTIBODY-DEPENDENT DAMAGE TO SCHISTOSOMULA
    BUTTERWORTH, AE
    STURROCK, RF
    HOUBA, V
    MAHMOUD, AAF
    SHER, A
    REES, PH
    [J]. NATURE, 1975, 256 (5520) : 727 - 729
  • [5] DECHATELET LR, 1978, BLOOD, V52, P609
  • [6] FABIAN I, 1985, BLOOD, V65, P990
  • [7] FUJISAWA T, 1990, J IMMUNOL, V144, P642
  • [8] GLASPY JA, 1990, EXP HEMATOL, V18, P1137
  • [9] GLEICH GJ, 1986, ADV IMMUNOL, V39, P177
  • [10] IDENTIFICATION OF AN ALVEOLAR MACROPHAGE-DERIVED ACTIVITY IN BRONCHIAL-ASTHMA THAT ENHANCES LEUKOTRIENE-C4 GENERATION BY HUMAN EOSINOPHILS STIMULATED BY IONOPHORE-A23187 AS A GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR
    HOWELL, CJ
    PUJOL, JL
    CREA, AEG
    DAVIDSON, R
    GEARING, AJH
    GODARD, P
    LEE, TH
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (05): : 1340 - 1347