OBSTETRIC COMPLICATIONS AND AUTOANTIBODIES IN SCHIZOPHRENIA

被引：8

作者：

CHENGAPPA, KNR

NIMGAONKAR, VL

BACHERT, C

YANG, ZW

RABIN, BS

GANGULI, R

机构：

[1] WESTERN PSYCHIAT INST & CLIN,SCHIZOPHRENIA MODULE,DEPT PSYCHIAT,IMMUNOPSYCHIAT PROGRAM,PITTSBURGH,PA 15213

[2] UNIV PITTSBURGH,SCH MED,DEPT PATHOL,DIV IMMUNOPATHOL,PITTSBURGH,PA

[3] UNIV PITTSBURGH,CTR BRAIN BEHAV & IMMUN,PITTSBURGH,PA

[4] CARNEGIE MELLON UNIV,PITTSBURGH,PA 15213

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1995年 / 92卷 / 04期

关键词：

OBSTETRIC COMPLICATION; AUTOANTIBODY; SCHIZOPHRENIA; BRAIN; AUTOIMMUNITY;

D O I：

10.1111/j.1600-0447.1995.tb09582.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Our hypothesis stated that patients with schizophrenia who had obstetric complications (OC) were more likely to have autoimmune abnormalities than those without OC. OC were rated using a checklist. Anti-brain autoantibodies were measured in serum using an enzyme immunoassay. Autoantibodies to non-CNS tissues were detected using serological procedures. There were no significant differences between the two groups with respect to anti-brain antibodies, but patients with OC (n = 24) had a significantly higher prevalence of autoantibodies to non-CNS tissues than patients without OC (n = 25). Both groups were receiving neuroleptic drugs. OC may contribute to autoimmune abnormalities among patients with schizophrenia.

引用

页码：270 / 273

页数：4

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