PARATHYROID-HORMONE RELATED PEPTIDE CAN FUNCTION AS AN AUTOCRINE GROWTH-FACTOR IN HUMAN RENAL-CELL CARCINOMA

被引：116

作者：

BURTON, PBJ ^{[1
]}

MONIZ, C ^{[1
]}

KNIGHT, DE ^{[1
]}

机构：

[1] UNIV LONDON KINGS COLL HOSP,DEPT CHEM PATHOL,LONDON SE5 9RS,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90641-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parathyroid hormone related peptide (PTHrP) has been implicated in the cause of the hypercalcemia associated with a number of malignant tumours. The data presented here suggests that PTHrP (in addition to its known role of mediating hypercalcemia) may be involved in the autocrine regulation of growth of some tumours. Polyclonal PTHrP antiserum almost totally inhibited the growth of a human renal cell carcinoma cell line, known to secrete PTHrP, in vitro and growth was significantly inhibited by the competitive PTH antagonist PTH (3-34)NH2. © 1990.

引用

页码：1134 / 1138

页数：5

共 12 条

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