USE OF THE HORMONAL RESPONSE TO CLOMIPHENE CITRATE AS AN ENDOCRINOLOGIC INDICATOR OF OVARIAN AGING

被引：12

作者：

NADER, S

BERKOWITZ, AS

机构：

[1] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Medical School, #3.204 Houston, TX 77030, Houston

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 07期

关键词：

AGING; CLOMIPHENE CITRATE; GONADOTROPINS; OVARY;

D O I：

10.1093/oxfordjournals.humrep.a137463

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

We compared the gonadotrophin and oestradiol responses to clomiphene citrate (CC) in women aged 18-25 versus 35-40 years. Despite similar baseline hormone concentrations and the attainment of similar concentrations of the E and Z isomers of clomiphene, higher follicle stimulating hormone (FSH) concentrations were observed in the older women, possibly indicative of their ageing ovaries. Furthermore, diminished oestradiol responses occurred in a subgroup of women showing FSH hyper-responsiveness to CC. These preliminary results support the concept that the hormonal response to CC may be an indicator of approaching perimenopause.

引用

页码：931 / 933

页数：3

共 11 条

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