PANCREATIC ADENOCARCINOMA - REGRESSION-ANALYSIS TO IDENTIFY IMPROVED CYTOLOGIC CRITERIA

被引：63

作者：

COHEN, MB

EGERTER, DP

HOLLY, EA

AHN, DK

MILLER, TR

机构：

[1] Departments of Pathology, and Epidemiology and Biostatics, University of California, San Francisco, California

[2] Sacramento, California

[3] Northern California Cancer Center, Belmont, California

[4] Health Research and Policy, Stanford University, Stanford, California

来源：

DIAGNOSTIC CYTOPATHOLOGY | 1991年 / 7卷 / 04期

关键词：

FINE NEEDLE-ASPIRATION BIOPSY; CARCINOMA; STATISTICAL ANALYSIS; PANCREAS;

D O I：

10.1002/dc.2840070404

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The incidence of pancreatic adenocarcinoma is increasing and it is usually unresectable at the time of diagnosis. Consequently, fine-needle aspiration biopsy (FNAB) is being used more frequently for diagnosis. The reported sensitivity of diagnosing pancreatic adenocarcinoma by FNAB has varied between 50% and 100%. In an attempt to increase the diagnostic sensitivity, we retrospectively reviewed a series of pancreatic FNABs. Fifteen cytologic criteria were evaluated in 78 patients who had pancreatic FNABs. Of these patients, 49 had primary adenocarcinomas and 29 had benign, non-neoplastic lesions. Using a stepwise logistic regression analysis we identified three key cytologic criteria for this diagnosis. Our study identified anisonucleosis (P = 0.001), large nuclei (P = .007), and nuclear molding (P = .03) as the significant cytologic features for diagnosing pancreatic adenocarcinoma. In combination, these three criteria had a sensitivity of 98% and a specificity of 100%.

引用

页码：341 / 345

页数：5

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