RAT SURFACTANT PROTEIN-D ENHANCES THE PRODUCTION OF OXYGEN RADICALS BY RAT ALVEOLAR MACROPHAGES

被引：115

作者：

VANIWAARDEN, JF

SHIMIZU, H

VANGOLDE, PHM

VOELKER, DR

VANGOLDE, LMG

机构：

[1] UNIV UTRECHT,EIJKMAN WINKLER LAB MED MICROBIOL,3508 TD UTRECHT,NETHERLANDS

[2] NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DENVER,CO 80206

来源：

BIOCHEMICAL JOURNAL | 1992年 / 286卷

关键词：

D O I：

10.1042/bj2860005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2-mu-g/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.

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页码：5 / 8

页数：4

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