VIRAL HEMAGGLUTININ AUGMENTS PEPTIDE-SPECIFIC CYTOTOXIC T-CELL RESPONSES

被引:62
作者
ERTEL, C
MILLAR, NS
EMMERSON, PT
SCHIRRMACHER, V
VONHOEGEN, P
机构
[1] GERMAN CANC RES CTR,TUMOR IMMUNOL PROGRAM 0710,IM NEUENHEIMER FELD 280,D-69120 HEIDELBERG 1,GERMANY
[2] UNIV NEWCASTLE UPON TYNE,SCH MED,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
关键词
CO-STIMULATION; VIRUS; PEPTIDE; CYTOTOXIC T-LYMPHOCYTE;
D O I
10.1002/eji.1830231032
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In attempt to increase the induction of peptide-specific cytolytic T cells (CTL) we investigated the effect of the Newcastle disease virus (NDV) hemagglutinin-neuraminidase (HN) gene product on the activation of peptide-specific CTL. Spleen cells of CH3 mice immunized against the influenza nucleoprotein peptide 50-63 (NP 50-63) were restimulated in vitro (i) with peptide-pulsed syngeneic fibroblast cells (Ltk-) as antigen-presenting cells, which were in addition (ii) infected with NDV or (iii) stably transfected with the HN cDNA of NDV. A greater than sixfold increase in peptide-specific CTL responses was observed in cultures restimulated with peptide-pulsed Ltk- cells which coexpressed viral hemagglutinin due to either infection or transfection. A similar augmentation was seen in CTL responses against other types of antigen (major histocompatibility complex alloantigens, minor histocompatibility antigens of tumor antigens) when suboptimal cultures were stimulated with the respective antigen-presenting cells modified by NDV infection. These findings suggest that NDV or viral HN expressed on antigen-present in cells or tumor cells can exert a T cell co-stimulatory function.
引用
收藏
页码:2592 / 2596
页数:5
相关论文
共 28 条
[1]   USE OF SYNTHETIC PEPTIDES OF INFLUENZA NUCLEOPROTEIN TO DEFINE EPITOPES RECOGNIZED BY CLASS-I-RESTRICTED CYTOTOXIC LYMPHOCYTES-T [J].
BASTIN, J ;
ROTHBARD, J ;
DAVEY, J ;
JONES, I ;
TOWNSEND, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (06) :1508-1523
[2]   VIRUS-AUGMENTED TUMOR TRANSPLANTATION ANTIGENS - EVIDENCE FOR A HELPER ANTIGEN MECHANISM [J].
BOONE, CW ;
PARANJPE, M ;
ORME, T ;
GILLETTE, R .
INTERNATIONAL JOURNAL OF CANCER, 1974, 13 (04) :543-551
[3]   MOLECULAR-CLONING OF COMPLEMENTARY-DNA TO NEWCASTLE-DISEASE VIRUS, AND NUCLEOTIDE-SEQUENCE ANALYSIS OF THE JUNCTION BETWEEN THE GENES ENCODING THE HEMAGGLUTININ NEURAMINIDASE AND THE LARGE PROTEIN [J].
CHAMBERS, P ;
MILLAR, NS ;
BINGHAM, RW ;
EMMERSON, PT .
JOURNAL OF GENERAL VIROLOGY, 1986, 67 :475-486
[4]   LOCATION OF A NEUTRALIZING EPITOPE FOR THE HEMAGGLUTININ-NEURAMINIDASE GLYCOPROTEIN OF NEWCASTLE-DISEASE VIRUS [J].
CHAMBERS, P ;
NESBIT, M ;
YUSOFF, K ;
MILLAR, NS ;
SAMSON, ACR ;
EMMERSON, PT .
JOURNAL OF GENERAL VIROLOGY, 1988, 69 :2115-2122
[5]   T-CELL IMMUNITY TO THE JOINING REGION OF P210BCR-ABL PROTEIN [J].
CHEN, W ;
PEACE, DJ ;
ROVIRA, DK ;
YOU, SG ;
CHEEVER, MA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (04) :1468-1472
[6]   INVIVO PRIMING OF VIRUS-SPECIFIC CYTO-TOXIC LYMPHOCYTES-T WITH SYNTHETIC LIPOPEPTIDE VACCINE [J].
DERES, K ;
SCHILD, H ;
WIESMULLER, KH ;
JUNG, G ;
RAMMENSEE, HG .
NATURE, 1989, 342 (6249) :561-564
[7]  
FAYOLLE C, 1991, J IMMUNOL, V147, P4069
[8]  
GAO XM, 1991, J IMMUNOL, V147, P3268
[9]  
GAO XM, 1989, J IMMUNOL, V143, P3007
[10]   A METHOD FOR RAPID SCREENING OF RECOMBINANT PROTEINS FOR RECOGNITION BY LYMPHOCYTES-T [J].
HICKLING, JK ;
JONES, KR ;
YUAN, B ;
ROTHBARD, JB ;
BULOW, R .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (08) :1983-1987