TRANSIENT HYPEREMIA SUCCEEDS OLIGEMIA IN THE WAKE OF CORTICAL SPREADING DEPRESSION

被引：28

作者：

FABRICIUS, M ^{[1
]}

LAURITZEN, M ^{[1
]}

机构：

[1] RIGSHOSP,CLIN NEUROPHYSIOL LAB,DK-2100 COPENHAGEN,DENMARK

来源：

BRAIN RESEARCH | 1993年 / 602卷 / 02期

关键词：

CEREBRAL BLOOD FLOW; CORTICAL SPREADING DEPRESSION; MIGRAINE;

D O I：

10.1016/0006-8993(93)90701-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional cerebral blood flow (rCBF) was examined following single episodes of cortical spreading depression (CSD) in rat brain after an intravenous bolus injection of [C-14]iodoantipyrine. Cortical rCBF decreased to approximately 75% of control values during the first 60 min after CSD. This change was succeeded at 90-105 min by a small, transient flow increase. rCBF returned to normal at 120 min after CSD, and remained normal for the following 2 h. The same sequence of rCBF changes has been recorded in patients during migraine attacks. This study therefore supports the notion that CSD may serve as an animal model of migraine.

引用

页码：350 / 353

页数：4

共 23 条

[1] DELAYED HYPEREMIA FOLLOWING HYPOPERFUSION IN CLASSIC MIGRAINE - SINGLE PHOTON-EMISSION COMPUTED TOMOGRAPHIC DEMONSTRATION [J].

ANDERSEN, AR ;

FRIBERG, L ;

OLSEN, TS ;

OLESEN, J .

ARCHIVES OF NEUROLOGY, 1988, 45 (02) :154-159

[2]

BURES J, 1974, MECHANISM APPLICATIO

[3] REGIONAL CEREBRAL BLOOD-FLOW DURING SPREADING CORTICAL DEPRESSION IN CONSCIOUS RATS [J].

DUCKROW, RB .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (01) :150-154

[4] THE 21-AMINOSTEROID ANTIOXIDANT TIRILAZAD MESYLATE, U-74006F, BLOCKS CORTICAL HYPOPERFUSION FOLLOWING SPREADING DEPRESSION [J].

HALL, ED ;

SMITH, SL .

BRAIN RESEARCH, 1991, 553 (02) :243-248

[5] EXTRACELLULAR ION CONCENTRATIONS DURING SPREADING DEPRESSION AND ISCHEMIA IN THE RAT-BRAIN CORTEX [J].

HANSEN, AJ ;

ZEUTHEN, T .

ACTA PHYSIOLOGICA SCANDINAVICA, 1981, 113 (04) :437-445

[6] METABOLIC AND HEMODYNAMIC ACTIVATION OF POSTISCHEMIC RAT-BRAIN BY CORTICAL SPREADING DEPRESSION [J].

KOCHER, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (04) :564-571

[7] SOME METABOLIC CHANGES ACCOMPANYING LEAOS SPREADING CORTICAL DEPRESSION IN RAT [J].

KRIVANEK, J .

JOURNAL OF NEUROCHEMISTRY, 1961, 6 (03) :183-&

[8]

KRIVANEK J, 1962, PHYSIOL BOHEMOSLOV, V11, P383

[9] Patterns of cerebral integration indicated by the scotomas of migraine [J].

Lashley, KS .

ARCHIVES OF NEUROLOGY AND PSYCHIATRY, 1941, 46 (02) :331-339

[10] CORTICAL SPREADING DEPRESSION AS A PUTATIVE MIGRAINE MECHANISM [J].

LAURITZEN, M .

TRENDS IN NEUROSCIENCES, 1987, 10 (01) :8-13

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