NOVEL-APPROACH TO THE RING-OPENING OF 4-ISOXAZOLINES - ONE-POT SYNTHESIS OF ALPHA,BETA-ENONES

被引：12

作者：

CHIACCHIO, U

LIGUORI, A

RESCIFINA, A

ROMEO, G

ROSSANO, F

SINDONA, G

UCCELLA, N

机构：

[1] UNIV MESSINA,DIPARTIMENTO FARMACOCHIM,I-98168 MESSINA,ITALY

[2] UNIV ARCAVACATA RENDE,DIPARTIMENTO CHIM,I-87036 ARCAVACATA,ITALY

来源：

TETRAHEDRON | 1992年 / 48卷 / 01期

关键词：

D O I：

10.1016/S0040-4020(01)80585-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 4-isoxazoline derivatives with methyl iodide affords alpha-beta-enones in excellent yields. The novel rearrangement pathway, proceeding through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.

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收藏

页码：123 / 132

页数：10

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