THERAPY WITH I-125 LABELED INTERNALIZED AND NON-INTERNALIZED MONOCLONAL-ANTIBODIES IN NUDE-MICE WITH HUMAN COLON-CARCINOMA XENOGRAFTS

被引：9

作者：

ARONSSON, EF

GRETARSDOTTIR, J

JACOBSSON, L

BACK, T

HERTZMAN, S

LINDEGREN, S

KARLSSON, B

LINDHOLM, L

HOLMBERG, S

HAFSTROM, L

MATTSSON, S

机构：

[1] PHARM CANAG, S-40242 GOTHENBURG, SWEDEN

[2] GOTHENBURG UNIV, SAHLGRENS HOSP, DEPT SURG, S-41345 GOTHENBURG, SWEDEN

[3] UNIV LUND, MALMO GEN HOSP, DEPT RADIAT PHYS, S-21401 MALMO, SWEDEN

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 02期

关键词：

D O I：

10.1016/0969-8051(93)90105-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The therapeutic effects of I-125-labelled (18-97 MBq) monoclonal antibodies (MAb) C-242, C-215 and S-S.1 were studied in nude mice with human colorectal adenocarcinoma tumours. The antibodies were administered 2 or 10-16 days after implantation of the tumour cells. The monoclonal antibody C-242 was internalized into the tumour cells, C-215 was internalized to a lower degree while S-S.1 (unspecific MAb) was not internalized at all. No enhanced therapeutic effect of I-125-C-242 was observed, as a result of Auger electrons, compared with I-125-C-215 and I-125-S-S.1.

引用

页码：133 / 144

页数：12

共 42 条

[1] COMPARISON OF 7 IODINE-LABELED MONOCLONAL-ANTIBODIES IN NUDE-MICE WITH HUMAN COLON-CARCINOMA XENOGRAFTS [J].