CHANGED EXCRETION OF URINARY PROTEINS AND ENZYMES BY CHRONIC EXPOSURE TO LEAD

被引:33
作者
PERGANDE, M
JUNG, K
PRECHT, S
FELS, LM
HERBORT, C
STOLTE, H
机构
[1] HUMBOLDT UNIV BERLIN,UNIV HOSP CHARITE,DEPT UROL,RES DIV,SCHUMANNSTR 20-21,D-10098 BERLIN,GERMANY
[2] HANNOVER MED SCH,DEPT INTERNAL MED,DIV NEPHROL,W-3000 HANNOVER 61,GERMANY
关键词
HIGH-MOLECULAR-WEIGHT PROTEIN; LEAD NEPHROPATHY; LOW-MOLECULAR-WEIGHT PROTEIN; OCCUPATION; TUBULE; URINARY ENZYMES;
D O I
10.1093/ndt/9.6.613
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Fifteen various serum and urine parameters were evaluated as indicators of renal alterations induced by lead in 82 male workers of a battery plant chronically exposed to lead (median of blood lead concentration: 2.03 mumol/l). The control group comprised 44 non-exposed healthy volunteers (0.34 mumol/l). High-molecular-mass proteins (transferrin, immunoglobulin G (IgG), (albumin)) were determined in urine as markers of glomerular integrity; low-molecular-weight proteins and parenchymal enzymes (alpha1-microglobulin, beta2-microglobulin, retinol-binding protein, lysozyme, ribonuclease, N-acetyl-beta-D-glucosaminidase (NAG), alanine aminopeptidase (AAP), alkaline phosphatase (AP), gamma-glutamyltransferase (GGT)) as indicators of changes in the proximal tubule; Tamm-Horsfall glycoprotein and kallikrein as markers of the distal tubule. There was a positive correlation between tubular indicators and blood lead concentration as well as the erythrocyte protoporphyrin (EPP). About 30% of the lead-exposed workers showed an increased excretion of alpha1-microglobulin, NAG, ribonuclease, and/or Tamm-Horsfall protein, whereas the glomerular indicators remained unchanged. The combined determination of NAG and alpha1-microglobulin in urine could be helpful in the early detection of lead-induced changes in the nephron.
引用
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页码:613 / 618
页数:6
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