RNASE INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION OF H9 CELLS

被引：64

作者：

YOULE, RJ

WU, YN

MIKULSKI, SM

SHOGEN, K

HAMILTON, RS

NEWTON, D

DALESSIO, G

GRAVELL, M

机构：

[1] NINCDS, MOLEC MED & NEUROSCI LAB, BETHESDA, MD 20892 USA

[2] ALFACELL CORP, BLOOMFIELD, NJ 07003 USA

[3] UNIV NAPLES, DIPARTIMENTO CHIM ORGAN & BIOL, I-80134 NAPLES, ITALY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 13期

关键词：

AIDS; EOSINOPHIL-DERIVED NEUROTOXIN;

D O I：

10.1073/pnas.91.13.6012

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Onconase and bovine seminal RNase, two members of the RNase A superfamily, inhibit human immunodeficiency virus type 1 replication in H9 leukemia cells 90-99.9% over a 4-day incubation at concentrations not toxic to uninfected H9 celts. Two other members of the same protein family, bovine pancreatic RNase A and human eosinophil-derived neurotoxin, have no detectable antiviral activity, demonstrating a strikingly selective antiviral activity among homologous ribonucleases. The antiviral RNases do not appear to affect viral particles directly but inhibit replication in host cell cultures. Onconase, already in clinical trials for cancer therapy, and bovine seminal RNase have potential as antiviral therapeutics.

引用

页码：6012 / 6016

页数：5

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