THE INVOLVEMENT OF PINEAL-GLAND AND MELATONIN IN IMMUNITY AND AGING .1. THYMUS-MEDIATED, IMMUNORECONSTITUTING AND ANTIVIRAL ACTIVITY OF THYROTROPIN-RELEASING-HORMONE

被引：71

作者：

PIERPAOLI, W

YI, CX

机构：

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 27卷 / 2-3期

关键词：

Aging; Immunity; Melatonin; Pineal; Thymus; Thyrotropin-releasing hormone; Tyroxine;

D O I：

10.1016/0165-5728(90)90059-V

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Circadian, continued treatment with melatonin during the dark cycle produces changes in the blood level of thyroid hormones in aging mice. Thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) antagonize the involution of the thymus produced by prednisolone. This effect of TRH does not seem thyroid dependent. TRH restores antibody production in non-responder athymic nude mice but does not exert this effect in neonatally thymectomized mice. Moreover, this activity does not correlate with thyroxine levels. TRH exerts a powerful protective effect in mice challenged with encephalomyocarditis (EMC) virus. Presumably pineal melatonin exerts its varied regulatory functions via hypothalamic TRH. © 1990.

引用

页码：99 / 109

页数：11

共 25 条

[1]

BURGER HG, 1977, CLIN NEUROENDOCRINOL, P67

[2] LYMPHOCYTES, HORMONES AND AGING [J].

FABRIS, N ;

SORKIN, E ;

PIERPAOLI, W .

NATURE, 1972, 240 (5383) :557-+

[3] PEPTIDES IN BRAIN - NEW ENDOCRINOLOGY OF NEURON [J].

GUILLEMIN, R .

SCIENCE, 1978, 202 (4366) :390-402

[4]

HARBOUR DV, 1988, SOC NEUR ABSTR, V14

[5]

Maestroni G.J.M., 1981, PSYCHONEUROIMMUNOLOG, P405

[6]

MAESTRONI GJM, 1988, IMMUNOLOGY, V63, P465

[7]

MAESTRONI GJM, 1988, ANN NY ACAD SCI, V521, P140

[8]

MAESTRONI GJM, 1989, IN PRESS PINEAL RES, V7

[9] PROPYLTHIOURACIL INHIBITS CONVERSION OF L-THYROXINE TO L-TRIIODOTHYRONINE [J].

OPPENHEI.JH ;

SCHWARTZ, HL ;

SURKS, MI .

JOURNAL OF CLINICAL INVESTIGATION, 1972, 51 (09) :2493-+

[10]

PIERPAOL.W, 1972, EXPERIENTIA, V28, P1386

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