LOW-DOSE AMITRIPTYLINE IN THE TREATMENT OF CHRONIC PAIN

被引：68

作者：

MCQUAY, HJ

CARROLL, D

GLYNN, CJ

机构：

[1] Oxford Regional Pain Relief Unit, Churchill Hospital, Oxford

[2] Oxford Regional Pain Relief Unit, Churchill Hospital, Oxford

[3] Oxford Regional Pain Relief Unit, Churchill Hospital, Oxford

来源：

ANAESTHESIA | 1992年 / 47卷 / 08期

关键词：

PAIN; CHRONIC; ATARACTICS; ANTIDEPRESSANTS; TRICYCLIC; AMITRIPTYLINE;

D O I：

10.1111/j.1365-2044.1992.tb02383.x

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The analgesic efficacy of amitriptyline 25 mg was compared with placebo in 41 patients with chronic (more than 3 months) nonmalignant pain, using a double‐blind randomised multiple‐dose 3‐week treatment period crossover design. Amitriptyline 25 mg provided significantly greater efficacy than placebo, with significant differences evident within the first week. There was no significant difference on mood scores between amitriptyline and placebo. The results suggest that surprisingly low doses of amitriptyline may be effective without substantial adverse effects, that the effect is evident early, and that the effect is distinguishable from any effect of the amitriptyline on mood. Copyright © 1992, Wiley Blackwell. All rights reserved

引用

页码：646 / 652

页数：7

共 19 条

[1] PSYCHOGENIC FACIAL-PAIN - PRESENTATION AND TREATMENT [J].