COMPOUNDS INHIBITING PROSTAGLANDIN SYNTHESIS ISOLATED FROM IPOMOEA-PES-CAPRAE

被引：45

作者：

PONGPRAYOON, U

BAECKSTROM, P

JACOBSSON, U

LINDSTROM, M

BOHLIN, L

机构：

[1] UNIV UPPSALA, CTR BIOMED, DEPT PHARMACOGNOSY, BOX 579, S-75123 UPPSALA, SWEDEN

[2] THAILAND INST SCI & TECHNOL RES, BANGKOK 10900, THAILAND

[3] ROYAL INST TECHNOL, DEPT ORGAN CHEM, S-10044 STOCKHOLM 70, SWEDEN

来源：

PLANTA MEDICA | 1991年 / 57卷 / 06期

关键词：

IPOMOEA-PES-CAPRAE (L) R. BR; 2-HYDROXY-4,4,7-TRIMETHYL-1(4H)-NAPHTHALENONE; (-)-MELLEIN; EUGENOL; 4-VINYLGUAIACOL; PROSTAGLANDIN SYNTHESIS;

D O I：

10.1055/s-2006-960196

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed a inhibitory effect of prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinyl-guaiacol (4). Among the isolated compounds, 3 and 4 were the most active with IC50 values of 9.2 and 18-mu-M, respectively. For 1 and 2 the IC50 values were 230 and 340-mu-M, respectively. The influence of 1, 2, 3, and 4 on the formation of prostaglandins may partly explain a previously observed anti-inflammatory effect of the extract IPA.

引用

页码：515 / 518

页数：4

共 19 条

[1] METABOLITES OF LASIODIPLODIA-THEOBROMAE [J].