CHARACTERIZATION OF ATHEROSCLEROSIS WITH A 1.5-T IMAGING-SYSTEM

被引：77

作者：

GOLD, GE ^{[1
]}

PAULY, JM ^{[1
]}

GLOVER, GH ^{[1
]}

MORETTO, JC ^{[1
]}

MACOVSKI, A ^{[1
]}

HERFKENS, RJ ^{[1
]}

机构：

[1] STANFORD UNIV,DEPT RADIOL,STANFORD,CA 94305

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1993年 / 3卷 / 02期

关键词：

AORTA; DISEASES; MR; CHEMICAL SHIFT IMAGING; IMAGE PROCESSING; MAGNETIC RESONANCE (MR); SPECTROSCOPY; PULSE SEQUENCES; RAPID IMAGING; TISSUE CHARACTERIZATION;

D O I：

10.1002/jmri.1880030216

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

It is shown that a conventional 1.5-T magnetic resonance (MR) imaging system can help characterize some of the key components of atherosclerotic plaque ex vivo. Fresh human aorta with atheromata was suspended in solutions of agarose and manganese chloride and heated to body temperature. The specimens were imaged with modified Dixon and projection-reconstruction imaging sequences. The specimens were then examined histologically to obtain direct correlation between images, spectra, and histologic characteristics. The results show that vessel wall and plaque components can be identified by means of their MR characteristics and correlated with their histologic appearance. The authors were able to identify normal vessel wall components, such as adventitial lipids and smooth muscle. They were also able to identify and localize plaque components such as fibrous tissue, calcification, lipids, and possible areas of hemorrhage and hemosiderin deposition.

引用

页码：399 / 407

页数：9

共 33 条

[1] Stehbens W, The lipid hypothesis and the role of hemodynamics in atherogenesis, Prog Cardiovasc Dis, 33, pp. 119-136, (1990)
[2] Campbell J, Campbell G, Biology of the vessel wall and atherosclerosis, Clin Exp Hypertension Theor Pract, 11 A, pp. 901-913, (1989)
[3] Gussenhoven W, Essed C, Frietman P, Et al., Intravascular echographic assessment of vessel wall characteristics: a correlation with histology, Int J Cardiac Imaging, 4, pp. 105-116, (1989)
[4] Lundberg B, Chemical composition and physical state of lipid deposits in atherosclerosis, Atherosclerosis, 56, pp. 93-110, (1985)
[5] Blakenhorn D, Johnson R, Mack W, El Zein H, Vailas L, The influence of diet on the appearance of new lesions in human coronary arteries, JAMA: The Journal of the American Medical Association, 263, pp. 1646-1652, (1990)
[6] Kragel AH, Reddy SG, Roberts WC, Morphometric analysis of the composition of coronary arterial plaque in isolated unstable anginal pectoris at rest (abstr), Journal of the American College of Cardiology, 15, (1990)
[7] Fuster V, Stein B, Ambrose J, Badimon L, Badimon J, Chesebro J, Atherosclerotic plaque rupture and thrombosis: evolving concepts, Circulation, 82, pp. 47-59, (1990)
[8] Herfkens R, Higgins C, Hricak H, Et al., Nuclear magnetic resonance imaging of atherosclerotic disease, Radiology, 148, pp. 161-166, (1983)
[9] Merickei M, Carman C, Brookeman J, Mugler J, Brown M, Ayers C, Identification and 3‐D quantification of atherosclerosis using magnetic resonance imaging, Computers in Biology and Medicine, 18, pp. 89-102, (1988)
[10] Mohiaddin R., Longmore D, MRI studies of atherosclerotic vascular disease: structural evaluation and physiological measurements, Br Med Bull, 45, pp. 968-990, (1989)

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