SYNTHESIS AND ANTIFUNGAL ACTIVITIES OF ALANINE-EXCHANGED ANALOGS OF PRADIMICIN-A

被引：11

作者：

OKUYAMA, S ^{[1
]}

KAKUSHIMA, M ^{[1
]}

KAMACHI, H ^{[1
]}

KONISHI, M ^{[1
]}

OKI, T ^{[1
]}

机构：

[1] CARE OF OKUMURA J,BRISTOL MYERS SQUIBB RES INST,BRISTOL MYERS SQUIBB KK,2-9-3 SHIMO-MEGURO,TOKYO 153,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 03期

关键词：

D O I：

10.7164/antibiotics.46.500

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A series of pradimicin analogs were designed and synthesized to investigate the effect of the amino acid side chain on the antifungal activity. The alanine-exchanged analogs (3a approximately 3q) were synthesized from 4'-N-Cbz-pradimic acid by coupling with appropriate amino acids or their equivalents followed by deblocking. All the D-alpha-amino acid derivatives except D-proline analog, 3k retained the antifungal activity.

引用

页码：500 / 506

页数：7

共 8 条

[1] UBER TETRAZOLE .1. DIE SYNTHESE DES 5-[BETA-AMINO-ATHYL]-TETRAZOLS UND EINIGER TETRAZOLYL-(5)-METHYLDERIVATE [J].