CHARACTERIZATION AND MAPPING OF THE HUMAN SOX4 GENE

被引：59

作者：

FARR, CJ

EASTY, DJ

RAGOUSSIS, J

COLLIGNON, J

LOVELLBADGE, R

GOODFELLOW, PN

机构：

[1] UMDS, GUYS HOSP, DIV MED & MOLEC GENET, LONDON SE1 9RT, ENGLAND

[2] ST GEORGES MED SCH, DEPT ANAT, LONDON SW17 ORE, ENGLAND

[3] NATL INST MED RES, MRC, EUKARYOT MOLEC GENET LAB, LONDON NW7 1AA, ENGLAND

来源：

MAMMALIAN GENOME | 1993年 / 4卷 / 10期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1007/BF00361388

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SOX genes comprise a large family related by homology to the HMG-box region of the testis-determining gene SRY. We have cloned and sequenced the human SOX4 gene. The open reading frame encodes a 474 amino acid protein, which includes an HMG-box. The non-box sequence is particularly rich in serine residues and has several polyglycine and polyalanine stretches. With somatic cell hybrids, human SOX4 has been mapped to Chromosome (Chr) 6p distal to the MHC region. There is no evidence for clustering of other members of the SOX1, -2, and -3 or SOX4 gene families around the SOX4 locus.

引用

页码：577 / 584

页数：8

共 39 条

[1] ALEXANDERBRIDGES M, 1992, ADV ENZYME REGUL, V32, P149
[2] IDENTIFICATION OF A CORE MOTIF THAT IS RECOGNIZED BY 3 MEMBERS OF THE HMG CLASS OF TRANSCRIPTIONAL REGULATORS - IRE-ABP, SRY, AND TCF-1-ALPHA
ALEXANDERBRIDGES, M
ERCOLANI, L
KONG, XF
NASRIN, N
[J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 1992, 48 (02) : 129 - 135
[3] PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE
AVIV, H
LEDER, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) : 1408 - &
[4] BENNETT DC, 1985, J CELL SCI, V77, P167
[5] A HELIX-LOOP-HELIX PROTEIN RELATED TO THE IMMUNOGLOBULIN-E BOX-BINDING PROTEINS
CARR, CS
SHARP, PA
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (08) : 4384 - 4388
[6] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE
CHIRGWIN, JM
PRZYBYLA, AE
MACDONALD, RJ
RUTTER, WJ
[J]. BIOCHEMISTRY, 1979, 18 (24) : 5294 - 5299
[7] AN SRY-RELATED GENE EXPRESSED DURING SPERMATOGENESIS IN THE MOUSE ENCODES A SEQUENCE-SPECIFIC DNA-BINDING PROTEIN
DENNY, P
SWIFT, S
CONNOR, F
ASHWORTH, A
[J]. EMBO JOURNAL, 1992, 11 (10) : 3705 - 3712
[8] A CONSERVED FAMILY OF GENES RELATED TO THE TESTIS DETERMINING GENE, SRY
DENNY, P
SWIFT, S
BRAND, N
DABHADE, N
BARTON, P
ASHWORTH, A
[J]. NUCLEIC ACIDS RESEARCH, 1992, 20 (11) : 2887 - 2887
[9] SELECTIVE PROLIFERATION OF NORMAL HUMAN MELANOCYTES INVITRO IN THE PRESENCE OF PHORBOL ESTER AND CHOLERA-TOXIN
EISINGER, M
MARKO, O
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (06): : 2018 - 2022
[10] DROSOPHILA TRANSCRIPTIONAL REPRESSOR PROTEIN THAT BINDS SPECIFICALLY TO NEGATIVE CONTROL ELEMENTS IN FAT-BODY ENHANCERS
FALB, D
MANIATIS, T
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (09) : 4093 - 4103

← 1 2 3 4 →