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MELANIN-CONCENTRATING HORMONE IN THE HUMAN BRAIN

被引：53
作者：
MOURI, T
TAKAHASHI, K
KAWAUCHI, H
SONE, M
TOTSUNE, K
MURAKAMI, O
ITOI, K
OHNEDA, M
SASANO, H
SASANO, N
机构：
[1] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 2,1-1 SEIKYO CHO,SENDAI,MIYAGI 980,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT PATHOL 2,SENDAI,MIYAGI 980,JAPAN
[3] KITASATO UNIV,SCH FISHERIES SCI,SANRIKU,IWATE,JAPAN
来源：
PEPTIDES | 1993年 / 14卷 / 03期
关键词：
MELANIN-CONCENTRATING HORMONE; HYPOTHALAMUS; BRAIN; HUMAN; IMMUNOCYTOCHEMISTRY; RADIOIMMUNOASSAY; CHROMATOGRAPHY;
D O I：
10.1016/0196-9781(93)90158-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive peak in the position of human/rat MCH, which was eluted 9 min later than that of salmon MCH. Free-floating sections (40 mum) of the hypothalamus were immunostained. Positive MCH immunostaining was found in perifornical, tuberomammillary, and posterior nuclei. Numerous MCH-immunoreactive nerve fibers were observed throughout the hypothalamus. The presence of high concentrations of MCH in the human brain, in particular in the hypothalamus, suggests that MCH is a neurotransmitter, a neuromodulator, or a neurohormone in man.
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页码：643 / 646
页数：4
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