COMPARATIVE KINETIC-STUDY OF THE BINDING BETWEEN 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN AND RELATED LIGANDS WITH THE HEPATIC AH RECEPTORS FROM SEVERAL RODENT SPECIES

被引：8

作者：

NAKAI, JS

WINHALL, MJ

BUNCE, NJ

ROSENGREN, R

SAFE, S

机构：

[1] UNIV GUELPH,GUELPH WATERLOO CTR GRAD WORK CHEM,DEPT CHEM & BIOCHEM,GUELPH N1G 2W1,ON,CANADA

[2] TEXAS A&M UNIV,DEPT VET PHYSIOL & PHARMACOL,COLLEGE STN,TX 77843

来源：

JOURNAL OF BIOCHEMICAL TOXICOLOGY | 1994年 / 9卷 / 04期

关键词：

AH RECEPTOR; TCDD; PCDDS; PCDFS; KINETICS;

D O I：

10.1002/jbt.2570090405

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Kinetic analysis of the time course of association of [H-3]-2,3,7,8-tetrachlorodibenzo-p-dioxin with hepatic cytosol from five rodent species gave additional evidence for differences in the properties of the Ah receptor ligand binding subunit between species. A parallel study of the association of six tritiated polychlorinated dibenzo-p-dioxins and dibenzofurans with hepatic Ah receptor from Wistar rat and C57BL/6 mouse showed that their rank order for kinetic affinity did not correlate with the rank ordering of their toxic potency and may vary according to the source of the Ah receptor.

引用

收藏

页码：199 / 209

页数：11

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