STUDIES OF GD(III)-EXCHANGED Y-TYPE ZEOLITES RELEVANT TO MAGNETIC-RESONANCE-IMAGING

被引：52

作者：

BRESINSKA, I ^{[1
]}

BALKUS, KJ ^{[1
]}

机构：

[1] UNIV TEXAS, DEPT CHEM, RICHARDSON, TX 75083 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY | 1994年 / 98卷 / 49期

关键词：

D O I：

10.1021/j100100a029

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Gadolite, a positive oral contrast agent for magnetic resonance imaging (MRT) that is currently in clinical trials, is based on a gadolinium(III)-modified NaY zeolite. Studies relevant to the in vivo stability and efficacy of GaNaY as an MRI brightening agent are detailed in this paper, The stability of GdY at low pH as well as in the presence of Na+, K+, Mg2+, and Ca2+ at concentrations relevant to the gastrointestinal tract has been evaluated. The relaxivities (1/T-1 vs [Gd]) of aqueous GdY suspensions were measured at 40 MHz and room temperature. Both the thermal history and gadolinium loading in the zeolite were found to have a profound effect on the relaxivity.

引用

页码：12989 / 12994

页数：6

共 49 条

[1]

Balkus K.J., 1992, U.S.Patent, V5, P122, Patent No. 5122363

[2] MOLECULAR-SIEVE BASED MRI CONTRAST AGENTS [J].