EFFECTS OF D-TIMOLOL AND L-TIMOLOL ON OCULAR BLOOD-FLOW AND INTRAOCULAR-PRESSURE

被引：18

作者：

CHIOU, GCY

ZHAO, F

SHEN, ZF

LI, BHP

机构：

[1] Institute of Ocular Pharmacology, Departmenl of Medical Pharmacology and Toxicology, Texas A&M University College of Medicine, College Station, Texas

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1990年 / 6卷 / 01期

关键词：

D O I：

10.1089/jop.1990.6.23

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Effects of D-timolol and L-timolol on IOP were compared with two rabbit models. When the drug solution was injected into vortex vein, 1% D-timolol produced ocular hypotension just like 0.5% L-timolol except D-timolol was less potent than L-timolol to lower the IOP. On the other hand, when 0.5% of D-timolol and L-timolol were instilled into the rabbit eye on IOP recovery model both agents showed equipotency to delayed the IOP recovery. Effects of D-timolol and L-timolol on ocular blood flow were also studied with two rabbit models. D-Timolol at 0.5% did not affect the ocular pulsatile blood flow measured with Langham's pneumatonometer whereas 0.5% L-timolol significantly suppressed it. D-Timolol (0.5%) was found to increase retinal and choroidal blood flows measured with laser Doppler method whereas L-timolol suppressed it. These results indicate that D-timolol though less potent than L-timolol to lower IOP, is superior over L-timolol to improve the blood flow in retina and choroid. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：23 / 30

页数：8

共 32 条

[1]

Van Burskirk E.M., Fraunfelder F.T., Ocular β-blockers and systemic effects, Amer. J. Ophthalmol, 98, pp. 623-624, (1984)

[2]

Fraunfelder F.T., Meyer S.M., Systemic side effects from ophthalmic timolol and their prevention, J. Ocular Pharmacol, 3, pp. 177-184, (1987)

[3]

Nelson W.L., Fraunfelder F.T., Sills J.M., Arrowsmith J.B., Kuritsky J.N., Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution 1978–1985, Amer. J. Ophthalmol, 102, pp. 606-611, (1986)

[4]

Shore J., Fraunfelder F.T., Meyer S.M., Psychiatric side effects from topical ocular timolol, α β-adrenergic blocker, J. Clin. Psychopharmacol, 7, pp. 264-267, (1987)

[5]

Swenson E.R., Severe hyperkalemia as a comppication of timolol, a topically applied β-adrenergic antagonist, Arch. Intern. Med, 146, pp. 1220-1221, (1986)

[6]

Clark C.V., Mapstone R., Autonomie neuropathy in ocular hypertension, The Lancet, pp. 185-187, (1985)

[7]

Velde T.M., Kaiser F.E., Ophthalmic timolol treatment causing altered hypoglycemie responses in a diabetic patient, Arch. Intern. Med, 143, (1983)

[8]

Grunwald J.E., Effect of topical timolol on the human retinal circulation, Inv. Ophthalmol. Vis. Sci, 27, pp. 1713-1719, (1986)

[9]

Yan H.Y., Chiou G.C.Y., Effects of L-timolol, D-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method, Ophth. Res, 19, pp. 45-48, (1987)

[10]

Chiou G.C.Y., Girgis Z., Chiou F.Y., Effects of epinephrine on retinal and choroidal blood flow through different routes of drug administration, Ophth. Res, 20, pp. 293-297, (1988)

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