CONFORMATION OF THE PEPTIDE-HORMONE SOMATOSTATIN IN AQUEOUS-SOLUTION AND ORGANIC-SOLVENTS

被引：6

作者：

JACKSON, M ^{[1
]}

MANTSCH, HH ^{[1
]}

机构：

[1] NATL RES COUNCIL CANADA,INST BIODIAGNOST,WINNIPEG R3B 1Y6,MANITOBA,CANADA

来源：

VIBRATIONAL SPECTROSCOPY | 1992年 / 3卷 / 04期

关键词：

INFRARED SPECTROMETRY; CONFORMATIONAL ANALYSIS; PEPTIDE HORMONES; SOMATOSTATIN;

D O I：

10.1016/0924-2031(92)85010-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Fourier transform infrared spectroscopy was applied to the conformational analysis of somatostatin in H2O, (H2O)-H-2, dimethyl sulphoxide (DMSO)-(H2O)-H-2 and DMSO. The results suggest that in these solvents the peptide adopts a similar structure. In agreement with circular dichroism (CD) spectroscopic data, evidence for turn structures was found; however, there was no evidence for the intramolecular beta-sheet secondary structures proposed on the basis of Raman and CD spectroscopic results. Rather, the amide C=O and NH groups not involved in turns appear to be either hydrogen bonded to the solvent or free.

引用

页码：323 / 326

页数：4

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