MAPPING OF LOCUS FOR X-LINKED CONGENITAL STATIONARY NIGHT BLINDNESS (CSNB1) PROXIMAL TO DXS7

被引：21

作者：

BECHHANSEN, NT ^{[1
]}

MOORE, BJ ^{[1
]}

PEARCE, WG ^{[1
]}

机构：

[1] UNIV ALBERTA,DEPT OPHTHALMOL,EDMONTON T6G 2E1,ALBERTA,CANADA

来源：

GENOMICS | 1992年 / 12卷 / 02期

关键词：

D O I：

10.1016/0888-7543(92)90394-8

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A recombinant chromosome in a male affected with X-linked congenital stationary night blindness (CSNB1) provides new information on the location of the CSNB1 locus. A four-generation family with five males affected with X-linked CSNB was analyzed with five polymorphic markers for four X-chromosome loci spanning the region OTC (Xp21.1) to DXS255 (Xp11.22). Four of the males inherited the same X chromosome; one male inherited a chromosome that from OTC to DXS7, inclusive, was derived from the normal X chromosome of his unaffected grandfather and that from a location between DXS7 and DXS426 proximally was derived from the chromosome carrying the CSNB1 locus. This recombinant maps the CSNB1 locus in this family to a region on the short arm of the X chromosome proximal to the DXS7 locus. © 1992.

引用

页码：409 / 411

页数：3

共 15 条

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