PHARMACOKINETICS AND TISSUE DISTRIBUTION OF IOMEPROL IN ANIMALS

被引：24

作者：

LORUSSO, V ^{[1
]}

LUZZANI, F ^{[1
]}

BERTANI, F ^{[1
]}

TIRONE, P ^{[1
]}

DEHAEN, C ^{[1
]}

机构：

[1] BRACCO IND CHIM SPA,PRECLIN RES,DIV RES & DEV,I-20134 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 1994年 / 18卷

关键词：

CONTRAST MEDIA; SAFETY; PHARMACOKINETICS; PROTEIN BINDING; METABOLISM; TISSUE DISTRIBUTION; EXPERIMENTAL STUDY;

D O I：

10.1016/0720-048X(94)90090-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The pharmacokinetics of iomeprol, a new triiodinated nonionic radiographic contrast agent, has been studied in rats, rabbits and dogs. Following intravenous administration, iomeprol did not bind measurably to plasma proteins and was rapidly excreted in unchanged form, mostly through the kidneys. The compound was rapidly distributed to the plasma and thence to the extracellular spaces. Iomeprol did not accumulate in specific organs or tissues except for those involved in its elimination, i.e. the kidneys and the liver. However, 24 h after administration, less than 1% of the injected dose remained in the tissues. The overall profile was very similar to the published profiles of other radiographic contrast agents used in uroangiography.

引用

页码：S13 / S20

页数：8

共 34 条

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