DETERMINATION OF THEOPHYLLINE AND ITS METABOLITES IN RAT-LIVER MICROSOMES AND HUMAN URINE BY CAPILLARY ELECTROPHORESIS

被引：34

作者：

ZHANG, ZY

FASCO, MJ

KAMINSKY, LS

机构：

[1] SUNY ALBANY,SCH PUBL HLTH,DEPT ENVIRONM HLTH & TOXICOL,ALBANY,NY 12201

[2] NEW YORK STATE DEPT HLTH,WADSWORTH CTR,ALBANY,NY 12201

来源：

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1995年 / 665卷 / 01期

关键词：

D O I：

10.1016/0378-4347(94)00526-B

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A capillary electrophoretic (CE) method has been developed for the determination of theophylline and all of its identified and potential metabolites. The method is rapid, resolves all metabolites to baseline, and requires extraction of only some biological fluids. It has been applied to the analysis of theophylline metabolism by hepatic microsomes from rats treated with a variety of inducing agents for different forms of P450 enzymes which metabolize theophylline, and to human urine spiked with theophylline and its metabolites, and concentrated by solid-phase extraction.

引用

页码：201 / 208

页数：8

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