TARGETED MUTATION IN THE FAS GENE CAUSES HYPERPLASIA IN PERIPHERAL LYMPHOID ORGANS AND LIVER

被引:322
作者
ADACHI, M
SUEMATSU, S
KONDO, T
OGASAWARA, J
TANAKA, T
YOSHIDA, N
NAGATA, S
机构
[1] OSAKA BIOSCI INST,SUITA,OSAKA 565,JAPAN
[2] OSAKA MED CTR MATERNAL & CHILD HLTH,IZUMI,OSAKA 59002,JAPAN
关键词
D O I
10.1038/ng1195-294
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr) mutation is a leaky mutation in Fas. By means of gene targeting, we generated a mouse strain which is completely deficient in Fas. In addition to the massive production of lymphocytes, the Fas-null mice showed substantial liver hyperplasia, which was accompanied by the enlargement of nuclei in hepatocytes. The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.
引用
收藏
页码:294 / 300
页数:7
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