STRUCTURE OF CLOVANEMAGNOLOL, A NOVEL NEUROTROPHIC SESQUITERPENE-NEOLIGNAN FROM MAGNOLIA-OBOVATA

被引：22

作者：

FUKUYAMA, Y ^{[1
]}

OTOSHI, Y ^{[1
]}

KODAMA, M ^{[1
]}

HASEGAWA, T ^{[1
]}

OKAZAKI, H ^{[1
]}

机构：

[1] OTSUKA PHARMACEUT CO LTD,KAGASUNO,TOKUSHIMA 77101,JAPAN

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 31期

关键词：

D O I：

10.1016/S0040-4039(00)97653-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structure of novel sesquiterpene-neolignan, clovanemagnolol (1), isolated from the bark of Magnolia obovata has been elucidated on the basis of the extensive 2D-NMR analyses and finally substantiated by one-step biomimetic synthesis from caryophyllene oxide and magnolol. Clovanemagnolol has exhibited neurotrophic activity at 10-7 M on neuronal cell culture system of fetal rat cerebral hemisphere. © 1990.

引用

页码：4477 / 4480

页数：4

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