PRESENCE OF CALPAIN-II IMMUNOREACTIVITY IN SENILE PLAQUES IN ALZHEIMERS-DISEASE

被引：36

作者：

SHIMOHAMA, S ^{[1
]}

SUENAGA, T ^{[1
]}

ARAKI, W ^{[1
]}

YAMAOAKA, Y ^{[1
]}

SHIMIZU, K ^{[1
]}

KIMURA, J ^{[1
]}

机构：

[1] KYOTO UNIV,FAC MED,DEPT ORTHOPED SURG,SAKYO KU,KYOTO 606,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 558卷 / 01期

关键词：

CALPAIN-II; HUMAN BRAIN; ALZHEIMERS DISEASE; IMMUNOHISTOCHEMISTRY; SENILE PLAQUE; DYSTROPHIC NEURITE;

D O I：

10.1016/0006-8993(91)90722-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calpains are calcium-dependent neutral cysteine proteinases. We utilized a specific anti-calpain II antibody to examine immunohistochemically whether calpain II is associated with pathological changes in Alzheimer's disease (AD). Calpain II was mainly expressed in the neurons in control human brains. In AD brains, intense immunoreactivity was present in the dystrophic neurites of senile plaques. These results suggest that calpain II is involved in the pathogenesis of AD.

引用

页码：105 / 108

页数：4

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