MONITORING OF LASER AND FREEZING-INDUCED ABLATION IN THE LIVER WITH T1-WEIGHTED MR IMAGING

被引：131

作者：

MATSUMOTO, R ^{[1
]}

OSHIO, K ^{[1
]}

JOLESZ, FA ^{[1
]}

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT RADIOL,75 FRANCIS ST,BOSTON,MA 02115

来源：

JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING | 1992年 / 2卷 / 05期

关键词：

LASERS; LIVER; MR; 761.1214; RAPID IMAGING; TEMPERATURE MONITORING;

D O I：

10.1002/jmri.1880020513

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

During both interstitial laser ablation therapy and cryoablation therapy for liver tumors, real-time monitoring is necessary for assessment of ongoing thermal effects in tissue. With single-section images obtained every 30 seconds with a T1-weighted RARE (rapid acquisition with relaxation enhancement) sequence, signal intensity changes in both ex vivo and in vivo animal liver were readily seen. The reversible loss of signal intensity that took place during laser irradiation and the increased intensity at the beginning of cooling can be explained mainly by altered T1 due to temperature change. The frozen area was seen as a sudden decrease in signal intensity at 0-degrees-C due to a T2 decrease. This preliminary work showed that the protocol provides enough temporal and temperature resolution to accurately depict the extent of thermal damage, as confirmed at histologic examination. Signal intensity decreased linearly with temperature in the range 10-degrees-C-50-degrees-C, yielding a pixel-to-pixel temperature resolution of 5.37-degrees-C.

引用

页码：555 / 562

页数：8

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