ASSOCIATION OF DRY EYES AND DRY MOUTH WITH ANTI-RO SS-A AND ANTI-LA SS-B AUTOANTIBODIES IN NORMAL ADULTS

被引:25
作者
JACOBSSON, L
HANSEN, BU
MANTHORPE, R
HARDGRAVE, K
NEAS, B
HARLEY, JB
机构
[1] MALMO GEN HOSP,DEPT MED,RHEUMATOL SECT,S-21401 MALMO,SWEDEN
[2] VET ADM MED CTR,OKLAHOMA MED RES FDN,ARTHRITIS & IMMUNOL PROGRAM,OKLAHOMA CITY,OK 73104
[3] UNIV OKLAHOMA,OKLAHOMA CITY,OK
来源
ARTHRITIS AND RHEUMATISM | 1992年 / 35卷 / 12期
关键词
D O I
10.1002/art.1780351213
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To evaluate the extent to which seemingly healthy, mature adults with mild symptoms of dry eyes or dry mouth share the immunologic features found in patients with Sjogren's syndrome. Methods. Of 705 subjects in Malmo, Sweden (age range 52-72 years) who responded to a questionnaire, 35% reported some symptoms of dry eyes or mouth. A random subgroup of the symptomatic subjects (n = 77) and an age- and sex-matched control group from among the asymptomatic subjects (n = 32) were evaluated objectively by serologic testing and by various measures of exocrine gland function. Results. The symptomatic subjects had relatively impaired exocrine gland function and elevated levels of anti-Ro and anti-La (1.54-2.88-fold increase compared with the asymptomatic subjects, 95% confidence interval [CI] 1.41, 4.03). The 2 autoantibodies correlated with each other (r = 0.64, 95% CI 0.49, 0.78) as well as with selected clinical measures of glandular function. Conclusion. The association between self-reported symptoms of dry eyes or dry mouth and anti-Ro and anti-La, found in more than one-third of mature adults in this study, suggests that the immune abnormalities and exocrine gland dysfunction found in Sjogren's syndrome affect a substantial proportion of the general population.
引用
收藏
页码:1492 / 1501
页数:10
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