H-3-NORADRENALINE OUTFLOW INDUCED FROM ISOLATED ADVENTITIA AND INTIMA-MEDIA OF RABBIT AORTA BY ELECTRICAL-FIELD STIMULATION

被引：12

作者：

SCHROLD, J ^{[1
]}

NEDERGAARD, OA ^{[1
]}

机构：

[1] UNIV ODENSE, INST PHARMACOL, DK-5000 ODENSE, DENMARK

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1976年 / 39卷 / 02期

关键词：

D O I：

10.1016/0014-2999(76)90156-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Electrical field stimulation of the isolated adventitial and intima-medial layers of rabbit aorta preloaded with 3H-noradrenaline elicited a 3H outflow. The initial 3H outflow from adventitia was independent of external Ca2+ concentration. Each of the subsequent 3H outflows was mainly Ca2+ sensitive. All stimulation-induced 3H outflows from media were Ca2+ insensitive. The isolated adventitia is a suitable preparation to study electrical field stimulation-evoked release of 3H-noradrenaline. The stimulation-induced 3H outflow from aorta is of neuronal and extraneuronal origin.

引用

页码：423 / 427

页数：5

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