PLASMA-LEVELS OF TRAZODONE - METHODOLOGY AND APPLICATIONS

被引：23

作者：

ABERNETHY, DR

GREENBLATT, DJ

SHADER, RI

机构：

[1] TUFTS UNIV, SCH MED, DEPT PSYCHIAT, DIV CLIN PHARMACOL, BOSTON, MA 02111 USA

[2] TUFTS UNIV, SCH MED, DEPT MED, DIV CLIN PHARMACOL, BOSTON, MA 02111 USA

[3] TUFTS UNIV, NEW ENGLAND MED CTR HOSP, BOSTON, MA 02111 USA

来源：

PHARMACOLOGY | 1984年 / 28卷 / 01期

关键词：

D O I：

10.1159/000137941

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method uses GLC with nitrogen-phosphorus detection. Applicability of the method is demonstrated by a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.

引用

页码：42 / 46

页数：5

共 13 条

[1]

ABERNETHY DR, 1981, J PHARMACOL EXP THER, V217, P681

[2] TRAZODONE - A NEW ASSAY PROCEDURE AND SOME PHARMACOKINETIC PARAMETERS [J].